protease activated receptors การใช้

Granzyme B can also induce inflammation by processing cytokines PAR1 ( Protease activated receptor 1 ).
The receptor that has been identified is one of a newly identified class called protease activated receptors, or PARs for short.
Protease activated receptors are integral membrane proteins that are coupled to G-proteins and are activated by specific cleavage of the amino terminal sequence that exposes a new N-terminal sequence functions as a tethered ligand, which binds intramolecularly to activate the receptor.
Activated protein C binds to endothelial protein C receptor and subsequently cleaves the endothelial cell protease activated receptor-1, not only altering coagulation profiles but down-regulating pro-inflammatory and pro-apoptotic mediators, up-regulation of anti-inflammatory and anti-apoptotic pathways and stabilization of the endothelial cell barrier functions.
Acting via its specific cell membrane receptors ( protease activated receptors : PAR-1, PAR-3 and PAR-4 ), which are abundantly expressed in all arterial vessel wall constituents, thrombin has the potential to exert pro-atherogenic actions such as inflammation, leukocyte recruitment into the atherosclerotic plaque, enhanced oxidative stress, migration and proliferation of vascular smooth muscle cells, apoptosis and angiogenesis.